Distribution of Enzymes, Substrates and misc. molecules. during Salivary Gland development

This table is part of the Salivary Gland Development Database

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 Molecule |   Mesenchyme    |   Epithelium    |Species| Gland |Stage| Expt. Methd. |  Remarks   |  Reference     
======================================================================================================================
Actin     |        0        |++ basal cells in| Human |Submand|Adult|Immunohist    |Myoepith.   |Okura,M. 1993
          |                 |     ducts.      |       |       |     |              |cells.      |
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Cytokera- |        0        |Identification of| Human |Parotid|Adult|Immunohist    |Characterise|Draeger,A. 1991
tin (gen) |                 |   cell type     |       |       |     |              |components. |Okura,M. 1993
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Cytokera- |        0        |+ desmosomes     | Human |Submand|Adult|Immunogold    |No tonofil  |Zimmer,K.P. 1985
tin (gen) |                 |++ tonofilaments |       |Parotid|     |              |in acinii.  |
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Cytokera- |        0        |       +++       |Guinea |Submand|Wk4- |Immunofluor   |Ab KG8.13   |Marshak,G. 1987
tin (gen) |                 |                 | pig   |       |birth|              |broad spect.|
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Cytokera- |        0        |       +++       |Guinea |Submand|Wk4- |Immunofluor   |Ab KS8.58   |Marshak,G. 1987
tin 13&16 |                 |                 | pig   |       |  wk6|              |            |
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Cytokera- |        0        |  +++ to ++ in   |Guinea |Submand|Wk6- |Immunofluor   |Only larger |Marshak,G. 1987
tin 13&16 |                 |basal duct cells.| pig   |       |birth|              |ducts @birth|
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Cytokera- |        0        |+++ in ducts only| Human |Submax |Adult|Immunofluor   |Cytokeratin |Geiger,S. 1987
tin 19    |                 |  not acinii     |       |       |     |              |ab. panel   |
>-------------------------------------------------------------------------------------------------------------------------
Collagen- |       +++       |       +++       | Mouse |Submand| E13 |ISH,          |Only S.G.   |Reponen,P. 1992
  -ase IV |                 |                 |       |       |     |Tissue sect.  |epith. cells|
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Endopept- |   Expression increases with age.  |  Rat  |Submand|E18- |ISH,          |Physiolog.  |Dutriez, I. 1992
   -idase |     Whole mount, not localised.   |       |       |Adult|Tissue sect.  |fns.in adult|
-----------------------------------------------------------------------------------------------------------------
FasL      |        0        |  +++ specific   | Mouse |Submax |E16.5|Immunohist    |No Fas      |French,LE. 1996
          |                 |acinar cells only|       |       |E18.5|In-situ       |expression  |
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Folli-    |+++ mainly around|+ expression incr| Mouse |Submand|15,17|ISH to tissue |            |Ritvos,O. 1995
    statin|  acinar epith.  |    with age     |       |       |19dys|sections      |            | 
-------------------------------------------------------------------------------------------------------------------------
Folli-    |                 ++                |  Rat  |Submand|16-20|ISH to tissue |No details, |Roberts,V.J. 1994
    statin|         Location not stated       |       |       |days |sections      |Whole mount.| 
-------------------------------------------------------------------------------------------------------------------------
Folli-    |                 +                 | Human |  Not  |15-17|Northern.     |            |Turri,T. 1994  
    Statin|                                   |       |stated.| wks.|              |            |      
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Histamine | Mast cells and  |        0        |  Rat  |Submand|E10- |Immunohist,   |            |Nissinen,M.J. 1995
          |  nerve fibres.  |                 |       |       |adult|tissue sect.  |            |
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Histidine |                 |                 |       |       |E10  |ISH to tissue |ir-histamine|Nissinen,M.J. 1995            
Decarbox- |        0        |        0        |  Rat  |Submand|  to |sections.     |only in mast|           
     ylase|                 |                 |       |       |adult|              |cells&nerves|            
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Muc-1     |        0        |  ++ Ducts and   | Mouse |Submand|E15- |Immunohist,   |Expression  |Braga,V.M.M. 1992
          |                 |     acini       |       |       | E18 |ISH, RT-PCR   |starts E15  |
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Muc-1     |        0        | ++ Ducts only.  | Mouse |Submand|E18- |Immunohist,   |No acinar   |Braga,V.M.M. 1992
          |                 |                 |       |       |adult|ISH, RT-PCR   |expression. |
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Muc-1, 2  |        0        |+++ Intercalated |  Not  |  Not  |Adult|Immunohist,   |Cell surface|Gendler,S.J. 1995
  and 3   |                 |& striated ducts |stated |stated |     |ISH.          |            |Review.
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Muc-7     |        0        |+++ Mucous acinii|  Not  |Submand|Adult|Northern,     |Secreted    |Bobek,L.A. 1993
          |                 |      only.      |stated |Subling|     |ISH?          |            |Gendler,S.J. 1995 Review.
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Peroxidase|          Activity peak,           |  Rat  |Parotid|21day|Perox.activity|Increases,  |Redman,R.S. 1993
          |       75% of adult levels         |       |       |  pp |on substrate. |day1-adult. |
-----------------------------------------------------------------------------------------------------------------
pmp22     | ++ mesenchymal  |        0        | Mouse |Submand|E14.5|In-situ       |Low by E18.5|Baechner,D. 1996
    (mRNA)|  condensations  |                 |       |Submand|E16.5|              |            |
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          |                 |+++ Basophilic   |       |       |10-39|Immunohist,   |Expression  |Adi,M.M. 1994
S100      |        0        |cells of acini   | Human |Labial | wks |tissue sect.  |increses    |
          |                 |and ducts.       |       |       |     |              |with age.   |
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SOD       |        ?        |0 - ++ acinii.   |  Rat  |Not    |E16to|Immunohist,   |Appears in  |Munim,A. 1992
(Cu,Zn)   |                 |0 - +++ ducts.   |       |stated |adult|tissue sect.  |ducts at E19|
------------------------------------------------------------------------------------------------------------------------
SOD (Mn)  |        ?        |0 - ++ acinii.   |  Rat  |Not    |E19to|Immunohist,   |Adult levels|Munim,A. 1992
          |                 |0 - +++ ducts.   |       |stated |adult|tissue sect.  |reached P21 |
------------------------------------------------------------------------------------------------------------------------
Vimentin  |        0        |++ basal cells in| Human |Submand|Adult|Immunohist    |Myoepith.   |Okura,M. 1993
          |                 |     ducts.      |       |       |     |              |cells.      |
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Date of last revision: 28 May 1997 - 09:33:07

dh5@holyrood.ed.ac.uk